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MOSTLY MICROBES AND INFECTIOUS DISEASES
Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.
![Bacteria, Bacterial colony, Microbes, Sa](https://static.wixstatic.com/media/0f9988_4f32933275014d039fbfa047eee81b76~mv2.jpg/v1/fill/w_980,h_735,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/0f9988_4f32933275014d039fbfa047eee81b76~mv2.jpg)
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![Development of T cell antigen-based human coronavirus vaccines against nAb-escaping SARS-CoV-2 variants](https://static.wixstatic.com/media/0f9988_1527c607462343f2bc2002e884cdd70a~mv2.png/v1/fill/w_454,h_324,fp_0.50_0.50,q_95,enc_auto/0f9988_1527c607462343f2bc2002e884cdd70a~mv2.webp)
David Ojcius
Jun 13, 20242 min read
Development of T cell antigen-based human coronavirus vaccines against nAb-escaping SARS-CoV-2 variants
Currently approved vaccines have been successful in preventing the severity of #COVID19 and hospitalization. These vaccines primarily...
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![Clinical development of antivirals against SARS-CoV-2 and its variants](https://static.wixstatic.com/media/0f9988_b8be4ff04d4a43d894402339106ea8b6~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_b8be4ff04d4a43d894402339106ea8b6~mv2.webp)
David Ojcius
Mar 3, 20242 min read
Clinical development of antivirals against SARS-CoV-2 and its variants
Abstract The unceasing global spread of severe acute respiratory syndrome #coronavirus 2 (#SARSCoV2) calls for the development of novel...
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![A GWAS in the pandemic epicenter highlights severe COVID-19 risk locus introgressed by Neanderthals](https://static.wixstatic.com/media/0f9988_17f01376eabb4ca6a52c83ef7ece9a81~mv2.png/v1/fill/w_375,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_17f01376eabb4ca6a52c83ef7ece9a81~mv2.webp)
David Ojcius
Sep 3, 20231 min read
A GWAS in the pandemic epicenter highlights severe COVID-19 risk locus introgressed by Neanderthals
Large GWAS indicated that genetic factors influence the response to #SARSCoV2. However, sex, age, concomitant diseases, differences in...
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![Senolytics combat COVID-19 in aging](https://static.wixstatic.com/media/0f9988_fbe97995059144fd9541ebfbdb79f4b1~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_fbe97995059144fd9541ebfbdb79f4b1~mv2.webp)
David Ojcius
Jul 7, 20234 min read
Senolytics combat COVID-19 in aging
#aging increases vulnerability to respiratory viral infections, including by #SARSCoV2. Delval et al. established a causal role for...
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![3D culture models to study SARS-CoV-2 infectivity and antiviral candidates: From spheroids to biopri](https://static.wixstatic.com/media/0f9988_454cac82c7464103ac4ce3bc14eefafa~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_454cac82c7464103ac4ce3bc14eefafa~mv2.webp)
David Ojcius
Mar 12, 20231 min read
3D culture models to study SARS-CoV-2 infectivity and antiviral candidates: From spheroids to biopri
The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (#SARSCoV2) is receiving worldwide attention, due to the severity...
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![Infection of the oral cavity with SARS-CoV-2 variants: Scope of salivary diagnostics](https://static.wixstatic.com/media/0f9988_9747268491cc45b08022bd7c4721a606~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_9747268491cc45b08022bd7c4721a606~mv2.webp)
David Ojcius
Nov 2, 20229 min read
Infection of the oral cavity with SARS-CoV-2 variants: Scope of salivary diagnostics
Coronaviruses, including #SARSCoV2, have caused pandemics in the past two decades. The most prevalent SARS-CoV-2 variants of concern can...
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![Fasting as key tone for COVID immunity](https://static.wixstatic.com/media/0f9988_07bf300554fa489fbd21bb485292dee3~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_07bf300554fa489fbd21bb485292dee3~mv2.webp)
David Ojcius
Oct 1, 20226 min read
Fasting as key tone for COVID immunity
#SARSCoV2-induced #anorexia triggers systemic metabolic alterations. A new study shows that the ketone body β-hydroxybutyrate (BHB)...
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![Your first brush with coronavirus could affect how a fall booster works](https://static.wixstatic.com/media/0f9988_a358e887420a42308c781df6613304db~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_a358e887420a42308c781df6613304db~mv2.webp)
David Ojcius
Aug 23, 20224 min read
Your first brush with coronavirus could affect how a fall booster works
As #omicron-specific boosters near, scientists debate how ‘original antigenic sin’ will influence immune responses. In the beginning,...
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![Operation Nasal Vaccine—Lightning speed to counter COVID-19](https://static.wixstatic.com/media/0f9988_09d6c46e55db404095a5e2344443f604~mv2.png/v1/fill/w_226,h_287,fp_0.50_0.50,q_95,enc_auto/0f9988_09d6c46e55db404095a5e2344443f604~mv2.webp)
David Ojcius
Jul 23, 20226 min read
Operation Nasal Vaccine—Lightning speed to counter COVID-19
Just 10 months after the initial genome sequencing of the #SARSCoV2 virus, two mRNA vaccines were demonstrated to provide 95% efficacy...
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![Think All Viruses Get Milder With Time? Not This Rabbit-Killer](https://static.wixstatic.com/media/0f9988_f9d9c6579eea4f0cbadc64a5801a3a78~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_f9d9c6579eea4f0cbadc64a5801a3a78~mv2.webp)
David Ojcius
Jun 20, 20225 min read
Think All Viruses Get Milder With Time? Not This Rabbit-Killer
As #COVID19 death rate globally has fallen, it may be tempting to conclude that #coronavirus is becoming milder. But this not a given. A...
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![How long is your COVID vaccine good for? You can soon find out, thanks to a new test](https://static.wixstatic.com/media/0f9988_b3f99c490dd9405c96ea743204048d0a~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_b3f99c490dd9405c96ea743204048d0a~mv2.webp)
David Ojcius
Jun 17, 20223 min read
How long is your COVID vaccine good for? You can soon find out, thanks to a new test
Researchers have developed a rapid T-cell test (the dqTACT assay) that measures the activation of T cells in response to #COVID19. The...
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![COVID and smell loss: answers begin to emerge](https://static.wixstatic.com/media/0f9988_d2ae960ac5884061957ea51590f06ae4~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_d2ae960ac5884061957ea51590f06ae4~mv2.webp)
David Ojcius
Jun 11, 20223 min read
COVID and smell loss: answers begin to emerge
Smell disruption from #COVID19 is becoming less-common, but millions of people still have problems with their sense of #smell. The...
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![Haven't had COVID yet? It could be more than just luck](https://static.wixstatic.com/media/0f9988_36a7ce58edae443aaf6867271456372d~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_36a7ce58edae443aaf6867271456372d~mv2.webp)
David Ojcius
May 29, 20222 min read
Haven't had COVID yet? It could be more than just luck
Haven't had #COVID19 yet? It could be more than just luck. Simplest explanation: you have never come into contact with the virus....
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![US sexually transmitted infections surged to record high in 2020](https://static.wixstatic.com/media/0f9988_c2f3d5139d9647d3b7ee03cd8031b346~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_c2f3d5139d9647d3b7ee03cd8031b346~mv2.webp)
David Ojcius
Apr 13, 20223 min read
US sexually transmitted infections surged to record high in 2020
After briefly dropping in early months of the #COVID19 pandemic in 2020, rates of sexually transmitted infections in US then resurged...
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![What triggers severe COVID? Infected immune cells hold clues](https://static.wixstatic.com/media/0f9988_c0fe2572b75d458ab0704e19e563aba5~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_c0fe2572b75d458ab0704e19e563aba5~mv2.webp)
David Ojcius
Apr 6, 20224 min read
What triggers severe COVID? Infected immune cells hold clues
Two studies show that immune cells infected with #SARSCoV2 can stimulate a large inflammatory response via #inflammasome activation. In...
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![Outbreak at Shanghai Hospital Exposes Covid’s Risks to China’s Seniors](https://static.wixstatic.com/media/0f9988_dbc83815ad82462daf71a43c2396a300~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_dbc83815ad82462daf71a43c2396a300~mv2.webp)
David Ojcius
Apr 2, 20223 min read
Outbreak at Shanghai Hospital Exposes Covid’s Risks to China’s Seniors
A #COVID19 outbreak is ravaging a hospital for older adults in Shanghai, China. Workers said that deaths are increasing & resources are...
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![Are ‘COVID toes’ actually caused by the coronavirus?](https://static.wixstatic.com/media/0f9988_d6f015a13f554e4798cf8743270f3a9b~mv2.png/v1/fill/w_454,h_261,fp_0.50_0.50,q_95,enc_auto/0f9988_d6f015a13f554e4798cf8743270f3a9b~mv2.webp)
David Ojcius
Mar 17, 20224 min read
Are ‘COVID toes’ actually caused by the coronavirus?
A surge in people with discolored toes does not seem to be linked to #COVID19. New report suggests that #COVID toe could have been caused...
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![China, pummeled by an outbreak, adds Pfizer’s antiviral pills to its treatment protocol](https://static.wixstatic.com/media/0f9988_0ade36ddfc5147f89a49556399fda8a5~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_0ade36ddfc5147f89a49556399fda8a5~mv2.webp)
David Ojcius
Mar 17, 20222 min read
China, pummeled by an outbreak, adds Pfizer’s antiviral pills to its treatment protocol
China has revised the country’s pandemic guidelines to include the use of antiviral pills made by Pfizer, #Paxlovid, as the country...
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![Europe thought it was done with Covid-19. But the virus isn't done with Europe](https://static.wixstatic.com/media/0f9988_b59b2745aec340ad99a3bdd7a503f42e~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_b59b2745aec340ad99a3bdd7a503f42e~mv2.webp)
David Ojcius
Mar 16, 20223 min read
Europe thought it was done with Covid-19. But the virus isn't done with Europe
Europe thought it was done with #COVID19. The UK's daily case rate is still < 1/3 of what it was during the #Omicron peak, but cases are...
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![Covid Cases Linked to Brain Shrinkage, Cognitive Decline Months Later](https://static.wixstatic.com/media/0f9988_b6ab57023c4f46e5a81f88b9580c5330~mv2.png/v1/fill/w_454,h_341,fp_0.50_0.50,q_95,enc_auto/0f9988_b6ab57023c4f46e5a81f88b9580c5330~mv2.webp)
David Ojcius
Mar 12, 20221 min read
Covid Cases Linked to Brain Shrinkage, Cognitive Decline Months Later
Even a mild case of #COVID19 can damage the brain, leading to shrinkage equivalent to up to a decade of #aging, according to a new study....
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