Highlights Intratumor bacteria promote breast cancer metastatic recurrence in a preclinical model Cytosolic bacteria induce immune suppressive neutrophils via cGAS-STING-IL-17B Intra- and extracellular bacteria can play opposite roles in determining neutrophil states A bacteria invasion signature is associated with poor prognosis in breast cancer patients Summary Intratumor bacteria represent an understudied yet influential component of the cancer ecosystem, critically imping

Nicotinamide adenine dinucleotide (NAD(H)) and its phosphorylated form NADP(H) are vitamin B3-derived redox cofactors essential for numerous metabolic reactions and protein modifications. Various health conditions are associated with disturbances in NAD+ homeostasis. To restore NAD+ levels, the main biosynthetic pathways have been targeted, with nicotinamide (Nam), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) being the most prominent boosters. However, whi

Highlights MT is dominated by Saccharomyces and Lactobacillus. MT has high ester, JS features elevated aldehydes, reflecting regional sensory. Saccharomyces and Pichia correlate with esters. Abstract This research focused on Maotai-flavour Baijiu from three representative production regions in the Chishui River Basin, namely Maotai Town (MT), Jinsha (JS), and Renhuai (RH). By integrating metabolomics and macrogenomics techniques, the study analyzed the differences in volatile

Highlights A significant proportion (∼11%) of  bla KPC genes were chromosome-integrated in  P. aeruginosa . Tn 4401 /Tn 7247 -like structures were the major transposons mobilizing  bla KPC. Tn 4401 - and Tn 7247 -like structures differed in geographic distribution and plasmid/chromosome localization. IS 26  and IS 6100  formed prevalent chimeric structures with truncated transposons to mobilize  bla KPC. Integrative mobilizable elements (IMEs) facilitated inter-cellular trans