Summary Antibiotics are among medicine’s greatest successes, but resistance evolution threatens their continued efficacy. Decades of research have deepened our understanding of the mechanisms and evolutionary dynamics of antimicrobial resistance. More recently, advances in machine learning (ML) and artificial intelligence (AI) show promise in predicting antimicrobial resistance in pathogens based on rapid whole-genome sequencing and other accessible data. In this perspective,

Highlights Halococci differ from other haloarchaea by their thick cell wall structure. Currently no viruses are known to infect Halococci. Seven novel Halococcus strains were characterized and the genomes sequenced. The novel Halococcus strains contain predicted anti-viral defence mechanisms. Detected proviruses indicate that Halococci are infected by viruses in nature. Abstract Halococcus species are widely distributed in hypersaline environments and possess unusual cell wal

Highlights Gut microbiome CRC signature is universal across age groups and sequencing approaches Tumor-enriched microbes are concordant with fecal CRC signatures Increasing dietary fiber intake reduces the microbiome CRC signature score Fusobacterium subspecies show biogeographic variation in CRC enrichment Summary Numerous studies have linked gut microbiome alterations to colorectal cancer (CRC), but limited sample sizes and study heterogeneity have hampered cross-study comp

Highlights Climate stressors restructure soil microhabitats, reassembling microbial guilds that regulate C–N–P cycling and resilience. Cross-domain feedbacks link pore architecture and soil chemistry to microbiome functions and emergent soil health outcomes. Rhizosphere mechanisms (exudates, siderophores, ACC deaminase, ISR, AMF/N-fixing symbioses) provide actionable leverage points under stress. Integrative indicators connect physical, chemical, and biological metrics to soi