Highlights Maternal vitamin B12 deficiency aggravates offspring obesity Vitamin B12 deficiency reduces B. pseudolongum in dams and offspring Loss of B. pseudolongum during lactation worsens obesity in offspring Restoring B. pseudolongum or acetate alleviates this obesity via Ffar2-Ehhadh Summary Vitamin B12 deficiency during pregnancy and lactation is common, yet its mechanistic impact on reproductive outcomes and offspring health remains poorly understood. Here, we show that

Highlights Engineered GSDMs are tailored as VIDAs to sense viral protease VIDA is inert without infection and has potent antiviral effects in vitro and in vivo VIDA elicits a “kill-and-alert” antiviral immune response in mice AI-driven accelerated evolution generates safer and more potent VIDAs Summary While gasdermin (GSDM)-mediated pyroptosis is a potent immune effector, its antiviral potential remains largely untapped. Here, we introduce viral protease-initiated lytic cell

Highlights Bulk meta-transcriptomics separates recurrent and condition-specific responses. Heat ramp triggers a broader, more structured program than heat shock. WGCNA, GO and motif analyses identify recurrent non-specific modules. Heat ramp-specific signatures link ribosome biogenesis and proteostasis. Stress-responsive modules show limited overlap with evolutionarily young genes. Abstract A central challenge in biology is to distinguish transcriptional responses that recur

Highlights Seeds can transmit a subset of associated bacteria to the next plant generation. Seed-associated bacteria can influence germination, nutrient acquisition, and pathogen suppression. Seed-focused SynComs enable tests of bacterial persistence, seed-to-seedling transfer and effects on crop traits. Abstract Seeds represent specialized, low-biomass microbial niches that facilitate the transmission of the plant-associated microbiota from one generation to another. Residin