Highlights The S. maltophilia MntH importer contributes to H2O2 resistance and intracellular survival The Mn exporter MntP limits toxicity even at sub-inhibitory Mn²⁺ concentrations The S. maltophilia MntR regulated genes include the extracytoplasmic TBDR-pTFP module The TBDR-pTFP locus is specifically induced under combined Mn2+ and Fe2+ limitation S. maltophilia Mn homeostasis is linked to iron availability and oxidative stress responses ABSTRACT Manganese homeostasis is es

Highlights Bifidobacterium stercoris KC84 alleviates IBS-D-like symptoms in mouse and rat models KC84 modulates serotonin-related pathways associated with diarrhea KC84 induces IFN-β production from colonic dendritic cells IFN-β is associated with reduced intestinal smooth muscle contractility Abstract Irritable bowel syndrome with diarrhea (IBS-D) is a prevalent disorder that significantly impairs quality of life, yet therapeutic advances remain limited. Serotonin dysregulat

Highlights Maternal helminths promote offspring antiviral immunity via the microbiota Helminth-altered microbiota produce IPA, which drives antiviral protection IPA induces lung epithelial type I interferon responses to promote antiviral immunity Helminth-endemic human microbiota are enriched in the tryptophan metabolism pathway Summary Maternal environmental exposures can alter microbiome composition and lead to changes in offspring immunity. Industrialization has led to sig

Abstract The circadian clock enables organisms to predict daily environmental changes and synchronise their physiology and behaviour accordingly. Macrophages, key sensor cells in the innate immune system, exhibit cell-autonomous circadian rhythmicity. This circadian rhythmic behaviour is synchronised to the central clock in the hypothalamus as a result of neural, and hormonal signals. Macrophage rhythms and responses involve sensing temporal cues, integrating information from