Highlights First global review linking polyphasic taxonomy to cyanobacterial metabolites in mangroves Catalogs cyanobacterial strains recognized only by modern morphological and molecular data Reveals high cyanobacterial diversity across mangrove ecosystem, including novel taxa Highlights diverse bioactivities: antimicrobial, anticancer, toxins, bioplastic Bridges taxonomy with biotech applications in drugs, agrochemicals, dyes, biofuels Abstract Extensive exploration of less

Highlights Sexual abstinence activates the hypothalamic-pituitary-adrenal (HPA) axis Sexual abstinence promotes tumor progression by inducing pregnenolone production Pregnenolone facilitates the formation of H3K9me3 to suppress ERV replication Pregnenolone antagonist is a highly promising candidate for anti-tumor therapy Summary Research into steroid hormones shaping tumor biology has gained increasing attention. Using multiple mouse tumor models, we show that pregnenolone pr

Highlights The gut metagenome is correlated with a host’s exhaled breath volatilome We devise a method to capture mouse breath using a murine ventilator Gnotobiotic mouse models help identify microbial contributions to exhaled breath The breath volatilome can signal the presence of the asthma-associated species  E. sireaum Summary The gut microbiota is crucial to health, yet implementation of microbiota-based therapeutics is limited by the lack of rapid diagnostics. We hypoth

Highlights Development of mouse model that closely mimics Haemophilus influenzae-mediated COPD exacerbation. Gene targeting approach reveals that cytosolic phospholipase 2-a (cPLA2-a) alters lung inflammatory response using COPD exacerbation experimental model. Also, cPLA2-a contributes to airway epithelium thickening in this clinical manifestation. Novel mechanism of bacterial infection-mediated COPD exacerbation involving cPLA2a. ABSTRACT Among the characteristics of chroni

The  history of dental treatments  dates back to thousands of years. The scope of this article is limited to the pre-1981  history . The earliest known example of  dental caries  manipulation is found in a  Paleolithic  man, dated between 14,160 and 13,820  BP . The earliest known use of a  filling  after removal of decayed or infected  pulp  is found in a Paleolithic who lived near modern-day  Tuscany , Italy, from 13,000 to 12,740 BP. Although inconclusive, researchers have

Highlights BPR2-D2, a coumarin derivative, is able to inhibit Chikungunya virus (CHIKV) RNA replication with a high selective index. BPR2-D2 can inhibit replication of Sindbis virus, which is an arthritogenic alphavirus as CHIKV The CHIKV replicon systems, which can be surrogates for studying CHIKV RNA replication, are applicable and convenient for antiviral screening. ABSTRACT Chikungunya virus (CHIKV), an alphavirus in the  Togaviridae  family, is transmitted to humans thro

Highlights Alternative splicing has been implicated in the regulation of a variety of genes Intron retention is the most frequent alternative splicing event in fungi We critically identified the gaps in the role of alternative splicing in fungi We proposed a practical roadmap to fill these gaps. ABSTRACT Assigning mechanistic and functional associations to most of the widespread splicing diversity in fungi has been one of the continuous and most intriguing challenges in the f

Porphyromonas gingivalis  is a keystone pathogen in periodontitis, known for its ability to invade gingival epithelial cells and persist intracellularly. Conventional antimicrobials are often ineffective against intracellular pathogens, and natural products remain poorly explored in this context. Here, we investigated the antimicrobial effects of  Boswellia serrata  extract and its bioactive compounds on the dynamics of  P. gingivalis  infection   in human gingival epithelial

Highlights Senescent cells drive aging, chronic disease, and tissue dysfunction Senotherapeutics span senolytics, senomorphics, immunotherapy, and restoration Target selection, screening readouts, and delivery platforms are linked to senescent-state biology to improve selectivity and translation Abstract Cellular senescence is a stress-induced cellular state that contributes to tissue dysfunction, chronic inflammation, and a broad range of aging-associated pathologies. The ac

Highlights Cancer cells hijack mitochondria from many immune cells Mitochondria loss by immune cells impairs innate and adaptive anti-tumor immunity Fusion of hijacked and endogenous cancer cell mitochondria triggers cGAS STING activation cGAS-STING activation promotes lymph node metastasis through type I interferon signaling Summary Although the immune system is a significant barrier to tumor growth and spread, established tumors evade immune attack and frequently colonize i

Highlight T6SS effector TseVF demonstrates apparent bacterial killing activity in the periplasm. TseVF interacts with phosphate lipid molecules and compromises the integrity of the cell membrane. The C-terminal region of TseVF is responsible for its bactericidal activity. 4. TsiVF binds to and neutralizes TseVF toxicity. TseVF secretion and bactericidality requires the C terminus of a cognate VgrG protein (TssI2_b). Abstract Vibrio fluvialis  ( V. fluvialis ) is a halophilic

Highlights A total of 833 glacier-derived potential pathogens were identified across habitats. Altitude and TOC drive distinct patterns of pathogen diversity in glacier habitats. Moraine and cryoconite are key sources of downstream pathogen dispersal. Community assembly is mainly stochastic, with network structure shaping selection. Cryospheric biosafety risks emerge via airborne and meltwater transmission pathways. Abstract Glacier retreat driven by global warming is releasi

Parabacteroides  is a  Gram-negative ,  anaerobic , non- spore -forming genus from the family  Tannerellaceae . First isolated from fecal specimen in 1933, type strain  Parabacteroides distasonis  was originally classified under the name  Bacteroides distasonis.  The strain was re-classified to form the new genus  Parabacteroides  in 2006.  Parabacteroides  currently comprise 21 phylogenetically, ecologically, and metabolically diverse species, 11 of which are listed in the t

Highlights Bacillus sp. HC-9 controls honeysuckle leaf spot caused by A. alternata. Strain HC-9 inhibits eight phytopathogenic fungi with strong antifungal activity. Strain HC-9 induces ROS and activates defense enzymes in honeysuckle leaves. Field trials show HC-9 achieves up to 80.52% disease control efficiency. Abstract Honeysuckle leaf spot disease, caused by Alternaria alternata , severely affects the yield and quality of honeysuckle crops. Biological control using nati

Highlights Identification of the TamA protein as a highly conserved antigen across diverse Klebsiella pneumoniae strains, making it an ideal target for a broad-spectrum subunit vaccine. Development and evaluation of a recombinant TamA protein vaccine that significantly enhances immune protection against a highly virulent Klebsiella pneumoniae infection in a murine model. Demonstration of TamA-induced specific antibodies that effectively inhibit bacterial adherence to epithe

Chlamydiosen  sind durch verschiedene  Chlamydien  (bestimmte  Bakterienarten ) verursachte  Infektionskrankheiten . Sie betreffen das  Auge  (als  Trachom ), die  Atemwege  und die  Lunge  (als  Pneumonie ) und den  Urogenitaltrakt  (Harn- und Geschlechtsorgane) als  sexuell übertragene Krankheit . Von  genitalen  Chlamydien-Infektionen sind überwiegend Jugendliche und junge Erwachsene im Alter von 15 bis 24 Jahren betroffen. Urogenitale Chlamydien-Infektionen verlaufen häuf

Highlights Phospholipid diversity shapes membrane properties for growth and stress adaptation Bacteria remodel phospholipid head groups and acyl chains to resist antimicrobials Phospholipid and its metabolism serve as promising potential antibacterial targets Abstract Bacterial infections have posed a serious threat globally. The discovery of new targets and the development of novel antimicrobial agents are urgently needed to combat these bacterial infections. The bacterial m

Highlights First systematic report of Niallia taxi BN5 with plant growth-promoting (PGP) activity, filling the Niallia PGP mechanism gap (previously studied for bioremediation/antibacterial functions). Multi-omics (genome/transcriptome/qPCR) show BN5 has a complete trp operon for constitutive IAA biosynthesis (17.64 μg/mL); tryptophan regulates trp/motility genes. BN5 enhances cucumber growth (height +24.29%, stem +11.23%), yield (+17.55%) and quality (vitamin C +17.2%, sol

Many shots seem to have “off-target” benefits, such as lowering the risk of dementia, studies have found. Let’s be clear. The primary reason to be vaccinated against shingles is that two shots provide 90 percent protection against a painful, blistering disease that a third of Americans will suffer in their lifetimes, one that can cause lingering nerve pain and other nasty long-term consequences. The most important reason for older adults to be vaccinated against the respirat

Highlights Distinct microbial communities are found in peritoneal dialysis (PD) and paired hemodialysis (HD) patients, despite similar microbiome diversity. Serum p-cresyl sulfate (PCS) levels are significantly lower in PD patients compared to paired HD patients. Altered microbial composition in PD patients, featuring more opportunistic pathogens and fewer beneficial bacteria, is linked to differences in metabolite profiles. Fecal transplant experiments confirm that the HD-as